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Obesity

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The simple definition of obesity, which can be applied to all types of obesity, is that there is an excess of body fat resulting mainly from excessive calorie intake associated with a tendency towards decreased physical activity. Obesity links physical consequences with an increased risk of mortality and morbidity (disease progression) as well as psychological and social disadvantages that may affect quality of life.
The origin of obesity is a problem of care and treatment. Medical management of excess weight is difficult because several aspects must be taken into account:  genetic determinism, the behavioural component and the sociocultural dimension.
Current knowledge of the regulation of body fat has improved allowing better defined therapeutic goals. Obesity results from a complex mixture of biological, psychological, behavioural, environmental and economic factors that are intertwined to give a heterogeneous clinical entity.
The body mass index allows quick diagnosis of obesity before using more sophisticated methods such as measuring body density, CT scans, etc. which are not routinely available methods.
The body mass index is just an index. It highlights an increase in risk factors with excessive body fat, and an increasing risk of mortality as body mass index increases.
Obesity is the manifestation of an imbalance resulting from the interaction of biological, primarily genetic factors with behavioural and environmental factors leading to increased energy storage in the form of fat in adipose tissue.
The regulation of energy reserves (fat) is complex and unique to each individual. It is the central nervous system that controls food intake and energy expenditure by hormonal and nervous means (neuropeptides Y, ghrelin, leptin, insulin, adiponectin, peptide YY). Obesity leads to an imbalance in the input and output of energy. Man has the ability to accumulate reserves but a low capacity to adapt to overeating. Weight gain leading to obesity is the translation of a fault in the system regulating the level of energy reserves.
Predisposition to gain weight also has a genetic component.
Obesity develops in several phases:
-the passage from "normal" weight to a little excess weight is the constitution phase called "dynamic";
-the transition to weight maintenance is the static phase;
-the phases of weight loss by therapeutic intervention;
-the phases of weight regain with the succession of failed diets.
The treatment of obese patients must first go through the relief of physical disorders, correction of psychological and metabolic disorders and help to support the constraints involved in a long-term diet plan. The concept of theoretical ideal weight is not tenable because individuals differ in body mass and size. Individualized weight goals are needed that must take account of all the biological, psycho physiological and psychological factors involved in resistance to restrictive diets.
It is first necessary to increase energy expenditure in daily life. There is also a dietary regime tailored to each individual, associated with a psychotherapeutic approach and complemented, in some cases, by medication.
Gastrointestinal surgery is reserved for severe obesity affecting health and resistant to previous therapy. Gastrointestinal surgery aims to reduce gastric volume (gastroplasty, gastric bypass), and is not risk free. The decision must be discussed by a team of experienced and qualified specialists: nutritionists, psychologists, anaesthesiologists and surgeons.
To treat obesity, we need a comprehensive approach at once psychological, somatic and social. The treatment of obesity is difficult, but significant results are obtained when the target weight is associated with improved quality of life and the treatment of complications.

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